Which laboratory tests are crucial for monitoring patients on methotrexate?

Monitoring patients on methotrexate is essential due to its potential effects on the liver and bone marrow. Methotrexate can cause hepatotoxicity, leading to liver damage over time, as well as myelosuppression, which can result in decreased blood cell counts. Therefore, periodic liver function tests help assess for any liver impairment that may arise from the medication, while complete blood counts are vital for detecting any significant drops in red blood cells, white blood cells, and platelets. This monitoring is crucial in preventing serious complications associated with methotrexate therapy, making the combination of liver function tests and complete blood counts particularly important for patient safety and effective management during treatment.